Can Air Pollution Contribute to Diabetes or Weight Gain?

Sarah HowardSarah Howard,
National Coordinator of the Diabetes-Obesity Spectrum Working Group

Of course what you eat can affect your risk of diabetes and obesity, but how about what you breathe? Can air pollution influence the risk of diabetes and obesity? Surprisingly, it might.

Long-term exposure to traffic-related air pollution is associated with an increased risk of type 2 diabetes in a number of studies. For example, African-American women living in Los Angeles had a higher risk of diabetes if their homes were located in areas with higher traffic-related air pollution levels, after controlling for other diabetes risk factors such as age, body mass index, exercise, and family history (Coogan et al 2012). Adults in Denmark had an increased risk of diabetes when exposed to higher levels of the traffic-related air pollutant nitrogen dioxide (NO2)—expecially those who had a healthy lifestyle, were physically active, and did not smoke—factors that should be protective against type 2 diabetes (Andersen et al 2012). Elderly women in Germany had a higher risk of diabetes when living in areas of higher traffic-related air pollution, after adjusting for diabetes risk factors as well as several non-traffic-related sources of air pollution (Kramer et al 2010).

Cross-sectional studies also often show associations between diabetes and air pollution, although somewhat inconsistently (Brook et al 2008). A US-wide analysis found that people living in counties with higher levels of fine particulate matter (PM 2.5) have higher rates of diabetes, even when pollution levels were within EPA guidelines (Pearson et al. 2010). Even at low air pollution levels, Michigan adults had higher insulin resistance—a hallmark of type 2 diabetes—when exposed to PM 2.5 air pollutants for short time periods (Brook et al 2012). Associations between insulin resistance and air pollution are also found in countries with higher air pollution levels. Iranian children, for example, exposed to higher air pollution levels had higher insulin resistance as well (Kelishadi et al 2009).

Air pollution may also increase the risk of developing type 1 diabetes, an autoimmune disease that often develops during childhood. Southern Californian children exposed to higher levels of the air pollutants ozone and sulfate between birth and diabetes diagnosis had an increased risk of type 1 diabetes (Hathout et al 2006). In people who already have diabetes (of any type), air pollution may increase the risk of diabetes-related death (Raaschou-Nielsen et al. 2012).

Weight gain may entail more than the “calories-in, calories-out” model assumes. African-American or Hispanic women in New York City carried air pollution monitors while pregnant that measured their exposure to polycyclic aromatic hydrocarbons (PAHs), which are produced by burning fuels like gasoline and oil. Their children were more than twice as likely to be obese by age 7 if the mothers were exposed to higher PAH levels while pregnant, as compared to mothers with the lowest expsoure levels (Rundle et al. 2012).

These human studies are backed up by animal evidence. Adult male rats and mice exposed to small particulate matter (PM 2.5) air pollutants show increased insulin resistance (Yan et al 2011; Sun et al 2009). Mice exposed to air pollutants (PM 2.5) early in life have increased insulin resistance and inflammation, as well as fat tissue (Xu et al 2010). Pregnant mice exposed to diesel exhaust fumes have offspring that are more susceptible to weight gain later in life than those unexposed (Bolton et al 2012). Most of these animal studies found the effects using a high-fat diet, like the typical American diet.

We do not know how important air pollutants are in the development of diabetes and obesity, as compared to other risk factors. But even if air pollution only accounts for a small portion of the overall risk of diabetes and obesity, exposures are so widespread and diabetes and obesity are so common, that even small reductions in air pollutant levels may have significant public health benefits with respect to these conditions.


Andersen ZJ, Raaschou-Nielsen O, Ketzel M et al 2012. Diabetes incidence and long-term exposure to air pollution: a cohort study. Diabetes Care 35(1):92-98.

Bolton JL, Smith SH, Huff NC et al. 2012. Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner. FASEB J. 26(11):4743-4754

Brook RD, Jerrett M, Brook JR et al. 2008. The relationship between diabetes mellitus and traffic-related air pollution. J.Occup.Environ.Med. 50(1):32-38.

Brook RD, Xu X, Bard RL et al. 2012. Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air pollution. Sci.Total Environ. Aug 14 E pub.

Coogan PF, White LF, Jerrett M et al. 2012. Air Pollution and Incidence of Hypertension and Diabetes in African American Women Living in Los Angeles. Circulation 125(6):767-772.

Dijkema MB, Mallant SF, Gehring U et al. 2011. Long-term Exposure to Traffic-related Air Pollution and Type 2 Diabetes Prevalence in a Cross-sectional Screening-study in the Netherlands. Environ.Health 10(1):76.

Hathout EH, Beeson WL, Ischander M et al. 2006. Air pollution and type 1 diabetes in children. Pediatr.Diabetes 7(2):81-87.

Kelishadi R, Mirghaffari N et al. 2009. Lifestyle and environmental factors associated with inflammation, oxidative stress and insulin resistance in children. Atherosclerosis 203(1):311-319.

Kramer U, Herder C, Sugiri D, et al. 2010. Traffic-related air pollution and incident type 2 diabetes: results from the SALIA cohort study. Environ.Health Perspect. 118(9):1273-1279.

Pearson JF, Bachireddy C, Shyamprasad S et al. 2010. Association between fine particulate matter and diabetes prevalence in the U.S. Diabetes Care 33(10):2196-2201.

Raaschou-Nielsen O, Sorensen M, Ketzel M et al. 2012. Long-term exposure to traffic-related air pollution and diabetes-associated mortality: a cohort study. Diabetologia  Aug 24 E pub.

Rundle A, Hoepner L, Hassoun A et al. 2012. Association of childhood obesity with maternal exposure to ambient air polycyclic aromatic hydrocarbons during pregnancy. Am.J.Epidemiol. 175(11):1163-1172.

Sun Q, Yue P, Deiuliis JA et al. 2009. Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation 119(4):538-546.

Yan YH, Chou CC, Lee CT, et al. 2011. Enhanced insulin resistance in diet-induced obese rats exposed to fine particles by instillation. Inhal.Toxicol. 23(9):507-519.

Xu X, Yavar Z, Verdin M et al. 2010. Effect of early particulate air pollution exposure on obesity in mice: role of p47phox. Arterioscler.Thromb.Vasc.Biol. 30(12):2518-2527.


One thought on “Can Air Pollution Contribute to Diabetes or Weight Gain?

  1. Many thanks for an excellent blog, informative and well referenced. Keep up the good work!
    Dr Martin Hum, Editor Optimum Nutrition magazine, UK

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s