Cutting-edge Science of Exposures

written by Nancy Hepp, MS
Research and Communications Specialist

Sometimes there are stories, studies or policy decisions in our quarterly Top 10 nomination list that don’t make the final cut but are still worthy of some extra conversation. Here’s an example of two stories that we considered for our most recent list:

graphic of oxidative DNA damage

Graphic from the NIH article, which they acquired courtesy of Bret Freudenthal. Read the full description on the NIH site.

From the National Institutes of Health: NIH scientists determine how environment contributes to several human diseases. Using a new imaging technique, National Institutes of Health researchers have found that the biological machinery that builds DNA can insert molecules into the DNA strand that are damaged as a result of environmental exposures. The study: Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide.

From New technology tracks carcinogens as they move through the body. Researchers for the first time have developed a method to track through the human body the movement of polycyclic aromatic hydrocarbons, or PAHs, as extraordinarily tiny amounts of these potential carcinogens are biologically processed and eliminated. The study: Human in vivo pharmacokinetics of [14c]dibenzo[def,p]chrysene by accelerator mass spectrometry following oral microdosing.

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