Review of the Berlin Workshop Concerning Low Dose Effects and Non-monotonic Dose response for EACs (Endocrine Active Chemicals)

Sharyle Patton
Director of CHE Special Projects

Read more about this workshop held September 11 – 13, 2012.

The official workshop report will be published in a few weeks by workshop organizers, but I want to give you a sense right away of the nature and content of discussions.

First, the workshop successfully brought together experts and researchers in toxicology, endocrinology and epidemiology with European risk assessment regulators to discuss the implications of low dose effects and non-monotonic dose response curves for risk/safety assessment—or, endocrinology meets toxicology. If exposures to toxic chemicals at the low levels currently measured in the environment can cause harm through endocrine disruption, then risk assessment may need to change its approaches to toxicity testing.

Members from the chemical industry and the public interest community also participated in the workshop discussions, but the focus of discussion for all was the possibility of integration of the principles of endocrinology into current risk assessment practices and whether such integration requires a major overhaul of standard risk assessment or whether a few tweaks here and there might be sufficient.

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