Review of the Evidence on Developmental Exposure to Certain Endocrine Disrupting Chemicals and Obesity

written by Sarah Howard
CHE Diabetes-Obesity Spectrum Working Group Coordinator

Sarah HowardA review article on prenatal exposure to endocrine disrupters and obesity was just published. Overall, it found that, “For certain EDCs, early life exposure may be associated with weight homeostasis later in life, however not necessarily in an obesogenic direction.” The review includes both human and laboratory evidence (19 studies) published since 1995. (The review did not include studies on BPA.) Here are their findings for the chemical classes included:

Organotins

Organotins are well-documented obesogens in laboratory studies. Human studies, however, are not available. Prenatal exposure to tributyltin causes adioposity in exposed mice, and these effects may be transmitted to future generations as well.

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